Informatics Publishing Limited

G. Valli ¹, K. Ramu ², P. Mareeswari ²

Affiliations
1 Department of Chemistry, SFR College for Women, Sivakasi, Viruthunagar District, Tamil Nadu-626123, IN
2 Department of Chemistry, SFR College for Women, Sivakasi, IN

Abstract

The Schiff base 1,3-bis(2-hydroxybenzylidene)thiourea was prepared from salicylaldehyde and thiourea by condensation method using standard procedure. Analgesic and antipyretic activities 1,3-bis(2- hydroxybenzylidene)thiourea Schiff base were studied using albino rats of both the sexes. Animals were divided into three groups, each consisting of four animals. Group 1 served as control and group 2 received standard drug. Group 3 received 250 mg/kg of 1,3-bis(2-hydroxybenzylidene)thiourea . For the determination of antipyretic activity, pyrexia was induced by 20% yeast suspension. The analgesic activity was determined by tail immersion method. The results obtained showed that the Schiff base was found to exhibit analgesic, antipyretic activities. The analgesic activity of the Schiff base compared to the standard drug pentazocine was found to be higher in the first hour and then the activity decreases slowly. The reduction in the rectal temperature for this compound was observed to be less than the standard drug paracetamol. PASS prediction of 1,3-bis(2- hydroxybenzylidene)thiourea schiff base was found to exhibit Laccase inhibitor and Monophenol monooxygenase inhibitor activities greater than 90% and can also possessed other activities like Corticosteroid sidechain- isomerase inhibitor, 3-Hydroxybenzoate 4-monooxygenase inhibitor greater than 80%.

Keywords

Salicylaldehyde, Thiourea, Analgesic, Antipyretic and PASS.

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K. Venkatesh Sharma ¹, K. Hanumantha Rao ², K. Ramu ³

Affiliations
1 CSE Dept. at Sri Indu College of Engineering & Technology, IN
2 Nagarjuna University,Guntur, IN
3 Sri Indu College of Engineering & Technology, JNTU Hyderabad, IN

Abstract

Server less distributed computing has received significant attention from both the industry and the research community. Among the most popular applications are the wide-area network file systems, exemplified by CFS, Far site, and Ocean Store. These file systems store files on a large collection of entrusted nodes that form an overlay network. They use cryptographic techniques to maintain file confidentiality and integrity from malicious nodes. Unfortunately, cryptographic techniques cannot protect a file holder from a denial-of-service (DoS) attack or a host compromise attack. Hence, most of these distributed file systems are vulnerable to targeted file attacks, wherein an adversary attempts to attack a small (chosen) set of files by attacking the nodes that host them. This paper presents Location Guard—a location hiding technique for securing overlay file storage systems from targeted file attacks. Location Guard has three essential components: 1) location key, consisting of a random bit string (e.g., 128 bits) that serves as the key to the location of a file, 2) routing guard, a secure algorithm that protects accesses to a file in the overlay network given its location key such that neither its key nor its location is revealed to an adversary, and 3) a set of location inference guards, which refer to an extensible component of the Location Guard. Our experimental results quantify the overhead of employing Location Guard and demonstrate its effectiveness against DoS attacks, host compromise attacks, and various location inference attacks.

Keywords

File Systems, Overlay Networks, Denial-Of-Service Attacks, Performance and Scalability, Location Hiding.

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K. Ramu ¹, K. Kishore Reddy ¹, M. Gowtham Reddy ¹, R. Thandaiah Prabu ¹

Affiliations
1 Department of Electronics and Communication, Prathyusha Institute of Technology and Management, IN

Abstract

The proposed E-shaped Microstrip patch antenna is designed for GSM and 3G applications. For this E Shaped antenna simulated results for main parameters such as return loss, bandwidth, radiation patterns and gains are also discussed here. In the simulation we achieved fr=1.2 GHz Gain=5.68, Directivity=6.74 and Return losses=-23.62dB. By changing feeding points fr=1.5GHz, Return Loss=-29dB was achieved for GSM Band and fr=1.9 GHz, Return loss=-32dB for 3 G band after fabrication. The Designing & simulation of this antenna is done in ADS Software and fabricated antenna was tested by network analyzer.

Keywords

GSM, 3G, Microstrip Antenna, GPS, ADS.

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G. Valli ¹, P. Mareeswari ², K. Ramu ², A. Thanga Thirupathi ³

Affiliations
1 S.F.R. College for Women, Sivakasi, Viruthunagar District, Tamil Nadu, IN
2 Department of Chemistry, S.F.R College for Women, Sivakasi, IN
3 Department of Pharmacology, SB College of Pharmacy, Anaikuttam, Sivakasi, IN

Abstract

The Schiff base 4-(4-hydroxy benzylidene amino)phenol was prepared from p-hydroxybenzaldehyde and 4-aminophenol by condensation method using standard procedure. Analgesic, antipyretic and CNS activities of 4-(4- hydroxy benzylidene amino) phenol Schiff base were studied using albino rats of both the sexes. Animals were divided into three groups, each consisting of four animals. Group 1 served as control and group 2 received standard drug. Group 3 received 250 mg/kg of 4-(4-hydroxy benzylidene amino) phenol. For the determination of antipyretic activity, pyrexia was induced by 20% yeast suspension. The analgesic activity was determined by tail immersion method. CNS depressant activity of the compound was measured by placing the rat individually in the actophotometer for 10 min. The results obtained showed that the Schiff base was found to exhibit analgesic, antipyretic and CNS activities. The analgesic activity of the Schiff base compared to the standard drug pentazocine was found to be higher in the first hour and then the activity decreases slowly. The reduction in the rectal temperature for this compound was observed to be less than the standard drug paracetamol. 4-(4-hydroxy benzylidene amino)phenol Schiff base of 250mg/kg possessed CNS stimulant activity with a probability <0.001. 4-(4-hydroxy benzylidene amino)phenol Schiff base was found to possess highest glutathione thiolesterase inhibitor activity as 86% and other activities greater than 80% as per the prediction using PASS (online bioactivity prediction software) .

Keywords

P-Hydroxybenzaldehyde, 4-Aminophenol, Analgesic, Antipyretic , CNS and PASS.

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